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Inhibitor Report for: Fragment-886

Name Class
Fragment-886TypeFragment inhibitor of Notum
Piperidine
Pyrazole
Other_Name (7)
Chemical_Nomenclature(4-chloro-2-methylpyrazol-3-yl)-piperidin-1-ylmethanone
FormulaC10H14ClN3O
CAS_number491828-56-9
MW227.69
PaperZhao_2022_ACS.Chem.Neurosci_13_2060
Structure7BD9
CommentNot inhibitor of Notum. Compound 51 Fragment 886 IC50 >1000 microM
Gene_locushuman-NOTUM
CID831977
FamilyPectinacetylesterase-Notum
InChIKeyKRGQOKCRZMRVRH-UHFFFAOYSA-N
CanonicalSMILESCN1C(=C(C=N1)Cl)C(=O)N2CCCCC2
InChIInChI=1S/C10H14ClN3O/c1-13-9(8(11)7-12-13)10(15)14-5-3-2-4-6-14/h7H,2-6H2,1H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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