ESTHER
Database
Home
Search
Text search
aql query
In Class
Query Builder
Preformed queries
Species
Structures
Mutations
Interactants
Diseases
Genes
Insecticides
Other
Full List
Queries for insecticide resistance
AQL exemples
Tools
Blast
HMMER
Clustal
Psiblast
Intra
Families
Overall Table
Tree Table &
Old Table
Tree Table
Old Table
Explore genes with AQL
Explore species with AQL
All figures of families
Biological
data
Structures
Table
Explore structure with AQL
Mutations
Mutation Viewer
Mutalign
Mutalign 2
Mutalign for insecticide resistance
Queries for insecticide resistance
Explore mutation with AQL
Interactants
Substrates
Inhibitors
Reactivators
Kinetic comparison tool
Inhibitor types
Substrate types
Reactivator types
Explore interactants with AQL
Diseases
Table
Explore disease with AQL
Basics on AChE
Kinetics notes
Gene structures
Molecular forms
AChE Family
Human AChE
ESTHER definition
What is up?
Likid
DB Explorer
Meetings
Suplementary Data
Latest modifications
Bibliography (all years)
Acknowledgments
& disclaimer
Inhibitor
Bibliography
Biblio print
Tree Display
AceDB Schema
XML Display
Feedback
Inhibitor Report for: Fragment-916
Name
Class
Fragment-916
Type
Fragment inhibitor of Notum
Carboxamide
Other_Name (6)
Chemical_Nomenclature
3-ethyl-5-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,2-oxazole-4-carboxamide
Formula
C11H13N3O3
CAS_number
438224-38-5
MW
235.24
Paper
Zhao_2022_ACS.Chem.Neurosci_13_2060
Structure
7BDB
Comment
Not inhibitor of Notum. Compound 53 Fragment 916 IC50 > 980+/-17 microM
Gene_locus
human-NOTUM
CID
842858
Family
Pectinacetylesterase-Notum
InChIKey
OZMHRDLCZDDXRS-UHFFFAOYSA-N
CanonicalSMILES
CCC1=NOC(=C1C(=O)NC2=NOC(=C2)C)C
InChI
InChI=1S/C11H13N3O3/c1-4-8-10(7(3)17-13-8)11(15)12-9-5-6(2)16-14-9/h5H,4H2,1-3H3,(H,12,14,15)
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page
and
ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster
Acknowledgements and disclaimer