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Substrate Report for: Glu-Phe-Ser-Pro

Name Class
Glu-Phe-Ser-ProTypePeptide
Pyrrolidine
Other_NameEFSP
Chemical_Nomenclature1-[2-[[2-[(2-amino-4-carboxybutanoyl)amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carboxylic acid
FormulaC22H30N4O8
MW478.50
PaperSzeltner_2003_J.Biol.Chem_278_48786
Structure1UOQ
CommentDerived from bradykinine a natural substrate. derived from Abz-Gly-Phe-Ser-Pro-Phe(NO2)-Ala a fluoerescent synthetic substrate. Glu-Phe-Ser-Pro-Phe(NO2)-Ala is the substrate used but some hydrolysis occurs even with the mutant enzyme and only the n-terminal part is seen in the structure
Gene_locuspig-ppce
CID22698093
FamilyS9N_PPCE_Peptidase_S9
InChIKeyZHGNQCAJUQNOTB-UHFFFAOYSA-N
CanonicalSMILESC1CC(N(C1)C(=O)C(CO)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)O)N)C(=O)O
InChIInChI=1S/C22H30N4O8/c23-14(8-9-18(28)29)19(30)24-15(11-13-5-2-1-3-6-13)20(31)25-16(12-27)21(32)26-10-4-7-17(26)22(33)34/h1-3,5-6,14-17,27H,4,7-12,23H2,(H,24,30)(H,25,31)(H,28,29)(H,33,34)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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