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Substrate Report for: Homatropine

Name Class
HomatropineTypeNot A/B H target
Drug
Azabicyclo
Other_Name (8)
Chemical_Nomenclature(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate
FormulaC16H21NO3
MW275.34
Paper (2)
Structure2DQZ
1MX5
CommentHomatropine (Equipin, Isopto Homatropine) is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). Homatropine is less potent than atropine and has a shorter duration of action. Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with AChE inhibitors
Gene_locushuman-CES1
CID3623
447234
FamilyCarb_B_Chordata
A85-Mycolyl-transferase
InChIKeyZTVIKZXZYLEVOL-UHFFFAOYSA-N
CanonicalSMILESCN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O
InChIInChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3
WikipediaHomatropine

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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