Homatropine (Equipin, Isopto Homatropine) is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). Homatropine is less potent than atropine and has a shorter duration of action. Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with AChE inhibitors