Substrate

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Substrate Report for: Homatropine

Name Class
HomatropineTypeNot A/B H target
Drug
Other_Name (8)
Chemical_Nomenclature(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate
FormulaC16H21NO3
MW275.34
PaperBencharit_2003_Nat.Struct.Biol_10_349
Bencharit_2006_J.Mol.Biol_363_201
Structure2DQZ
1MX5
CommentHomatropine (Equipin, Isopto Homatropine) is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil). Homatropine is less potent than atropine and has a shorter duration of action. Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with AChE inhibitors
Gene_locushuman-CES1
CID3623
447234
FamilyCarb_B_Chordata
A85-Mycolyl-transferase
InChIKeyZTVIKZXZYLEVOL-UHFFFAOYSA-N
CanonicalSMILESCN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O
InChIInChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3
WikipediaHomatropine

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer