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Inhibitor Report for: ICeD-1
Name
Class
ICeD-1
Type
Cyanide
Pyrrolidine
Other_Name
CW8
(2S,4S)-1-((S)-2-amino-2-cyclohexylacetyl)-4-fluoropyrrolidine-2-carbonitrile
Chemical_Nomenclature
1-(2-amino-2-cyclohexylacetyl)-4-fluoropyrrolidine-2-carbonitrile
Formula
C13H20FN3O
MW
253.32
Paper
Moore_2022_ACS.Chem.Biol_17_2595
Structure
7SVO
7SVN
Comment
ICeD-1 and ICeD-2 (inducer of cell death-1 and 2) function by modulating DPP9 and activating the caspase recruitment domain family member 8 (CARD8) inflammasome, eliminating HIV-1 infected cells
Gene_locus
human-DPP9
human-DPP8
CID
72617751
Family
DPP4N_Peptidase_S9
InChIKey
PITTXTFNBYNBSG-UHFFFAOYSA-N
PITTXTFNBYNBSG-SRVKXCTJSA-N
CanonicalSMILES
C1CCC(CC1)C(C(=O)N2CC(CC2C#N)F)N
InChI
InChI=1S/C13H20FN3O/c14-10-6-11(7-15)17(8-10)13(18)12(16)9-4-2-1-3-5-9/h9-12H,1-6,8,16H2
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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