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Substrate Report for: Imidapril

Name Class
ImidaprilTypePro-Drug
Drug
Not A/B H target
Other_Name (8)
Chemical_Nomenclature(4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
FormulaC20H27N3O6
CAS_number89371-37-9
MW405.4
Paper (11)
CommentImidapril is a prodrug. imidapril is converted by human-CES1 (not CES2 or AADAC) into its active form imidaprilat: an angiotensin-converting enzyme (ACE) inhibitor
Gene_locushuman-CES1
CID5464343
FamilyCarb_B_Chordata
InChIKeyKLZWOWYOHUKJIG-BPUTZDHNSA-N
CanonicalSMILESCCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C2=O)C)C(=O)O
InChIInChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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