With best wishes for the new year! from the ESTHER Team. The XVIth International Symposium on Cholinergic Mechanisms in Rehovot, Israel was a real success! A photo gallery is available on the Web Site Stereodivergent protein engineering of Candida antarctica lipase B (CALB) to access all possible stereoisomers of chiral esters with two stereo-centers is published by Xu et al. and structures are available (6J1P, 6J1Q, 6J1R, 6J1S, 6J1T) Furano[2,3-d]prymidine amides as Notum inhibitors are published by Atkinson et al. and structures are available (6T2H, 6T2K)