The ESTHER curators wish to all users and colleagues a happy new year! Enhanced alpha-Zearalenol hydrolyzing activity of a mycoestrogen-detoxifying lactonase by structure-based engineering is published by Xu et al. and structures are available (5IE4, 5IE5, 5IE6, 5IE7). Expression of acetylcholinesterase 1 is associated with brood rearing status in the honey bee, Apis mellifera is published by Kim et al.. Functional similarities between the Dictyostelium protein AprA and the human protein Dipeptidyl-Peptidase IV are published by Herlihy et al.. It relates the PhoPQ_related family and the DPP-IV family. A paper by Flitter et al. shows that Pseudomonas aeruginosa Cif sabotages the generation of host proresolving lipid mediators by rapidly hydrolyzing 14,15-EET