With best wishes for the new year! from the ESTHER Team. The XVIth International Symposium on Cholinergic Mechanisms in Rehovot, Israel was a real success! A photo gallery is available on the Web Site and also in ESTHER at the meeting page Meetings specifically on the XVI-ISCM at XVI-ISCM pictures (use the forward and reverse tag to browse pages) Structural and biophysical analyses of human N-Myc Downstream-regulated gene 3 (NDRG3) protein are published by Kim et al. and structures will be available soon (6L4B, 6L4G, 6L4H) Structural characterisation of melatonin as an inhibitor of the Wnt deacylase Notum is published by Zhao et al. and structures are available (6TR6, 6TR7). Comparative structural analysis of different Mycobacteriophage-derived mycolylarabinogalactan esterases (Lysin B Lysin_B_C_ter) is published by Korany et al.