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Inhibitor Report for: Kurarinone

Name Class
KurarinoneTypeNatural
Flavonoid
Other_Name (9)
Chemical_Nomenclature(2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)-2,3-dihydrochromen-4-one
FormulaC26H30O6
CAS_number34981-26-5
MW438.5
PaperSong_2019_Int.J.Biol.Macromol_131_201
Kumar_2021_Front.Pharmacol_12_737137
Sun_2022_Proc.Natl.Acad.Sci.U.S.A_119_
Structure7EBA
CommentKurarinone is a natural product found in Sophora flavescens, Sophora alopecuroides, Albizia julibrissin. Inhibits human-CES2 IC50 1.46+/-0.43, Ki 1.73 muM
Gene_locushuman-CES2
CID10812923
11982640
5318882
FamilyCarb_B_Chordata
InChIKeyLTTQKYMNTNISSZ-KESSSICBSA-N
CanonicalSMILESCC(=CCC(CC1=C2C(=C(C=C1O)OC)C(=O)CC(O2)C3=C(C=C(C=C3)O)O)C(=C)C)C
InChIInChI=1S/C26H30O6/c1-14(2)6-7-16(15(3)4)10-19-21(29)12-24(31-5)25-22(30)13-23(32-26(19)25)18-9-8-17(27)11-20(18)28/h6,8-9,11-12,16,23,27-29H,3,7,10,13H2,1-2,4-5H3/t16?,23-/m0/s1

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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