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Inhibitor Report for: Linagliptin

Name Class
LinagliptinTypeDrug
Purine
Gliptin
Quinazoline
Other_NameTradjenta
BI-1356
Trajenta
Ondero
Chemical_Nomenclature8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione. Linagliptin inhibits also fibroblast activation protein (FAP)
FormulaC25H28N8O2
CAS_number668270-12-0
MW472.54
Paper (23)
Structure2RGU
6Y0F
CommentLinagliptin is a purine and quinazoline derivative that functions as a potentiator of incretin and as long lasting dipeptidyl-peptidase IV inhibitor. It is used as a hypoglycemic agent in the treatment of Type II diabetes mellitus
Gene_locushuman-DPP4
human-FAP
CID10096344
FamilyDPP4N_Peptidase_S9
InChIKeyLTXREWYXXSTFRX-QGZVFWFLSA-N
CanonicalSMILESCC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C
InChIInChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
IupharLig6318
WikipediaLinagliptin

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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