The 14th International Symposium on Cholinergic Mechanisms (ISCM) took place in Hangzhou, China on May 5-9, 2013. It was a tremendous event thanks to Professor Karl Tsim and colleagues. Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with vildagliptin (3W2T) is available and published by Nabeno et al.. 3D structure of thermostable L2 lipase from thermophilic locally isolated Bacillus sp. L2. is available (4FDM) and published by Abd Rahman et al.. Crystal structures of E. coli native MenH and two active site mutants are available (4GDM, 4GEG, 4GEC) and published by Johnston et al. Structures of a self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii are available (4HXG, 4HXE, 4HXF) and published by Menyhard et al.. Crystal structures of A. Thaliana KAI2 Apo form, and in complex with smoke-derived karrikin (4JYP, 4JYM) are available and published by Guo et al.