Inhibitor Report for: MGL-Inhibitor-26
MGL-Inhibitor-26 | Type | Piperidine |
| | Carboxamide |
| | Pyrazole |
| Other_Name | Compound 26 |
| | compound-26 |
| Chemical_Nomenclature | (4-Benzylpiperidin-1-yl)(5-(4-hydroxyphenyl)-1-(3-methylbenzyl)-1H-pyrazol-3-yl)methanone |
| Formula | C30H31N3O2 |
| MW | 465.59 |
| |
| Paper | Aghazadeh Tabrizi_2018_J.Med.Chem_61_1340 |
| Comment | Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivative MAGL inhibitor (IC50 = 0.51 uM, Ki = 412 nM) with a good selectivity versus fatty acid amide hydrolase (FAAH), alpha/beta-hydrolase domain-containing 6 (ABHD6) and 12 (ABHD12) |
| Gene_locus | human-MGLL |
| Family | Monoglyceridelipase_lysophospholip |
| InChIKey | GZMWVVSFFYCRRT-UHFFFAOYSA-N |
| CanonicalSMILES | CC1=CC(=CC=C1)CN3C(=C2C=CC(=O)C=C2)C=C(N3)C(=O)N4CCC(CC4)CC5=CC=CC=C5 |
| InChI | InChI=1S/C30H31N3O2/c1-22-6-5-9-25(18-22)21-33-29(26-10-12-27(34)13-11-26)20-28(31-33)30(35)32-16-14-24(15-17-32)19-23-7-3-2-4-8-23/h2-13,18,20,24,31H,14-17,19,21H2,1H3 |
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