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Inhibitor Report for: MGL-Inhibitor-26

Name Class
MGL-Inhibitor-26TypePiperidine
Carboxamide
Pyrazole
Other_NameCompound 26
compound-26
Chemical_Nomenclature(4-Benzylpiperidin-1-yl)(5-(4-hydroxyphenyl)-1-(3-methylbenzyl)-1H-pyrazol-3-yl)methanone
FormulaC30H31N3O2
MW465.59
PaperAghazadeh Tabrizi_2018_J.Med.Chem_61_1340
CommentDiscovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivative MAGL inhibitor (IC50 = 0.51 uM, Ki = 412 nM) with a good selectivity versus fatty acid amide hydrolase (FAAH), alpha/beta-hydrolase domain-containing 6 (ABHD6) and 12 (ABHD12)
Gene_locushuman-MGLL
FamilyMonoglyceridelipase_lysophospholip
InChIKeyGZMWVVSFFYCRRT-UHFFFAOYSA-N
CanonicalSMILESCC1=CC(=CC=C1)CN3C(=C2C=CC(=O)C=C2)C=C(N3)C(=O)N4CCC(CC4)CC5=CC=CC=C5
InChIInChI=1S/C30H31N3O2/c1-22-6-5-9-25(18-22)21-33-29(26-10-12-27(34)13-11-26)20-28(31-33)30(35)32-16-14-24(15-17-32)19-23-7-3-2-4-8-23/h2-13,18,20,24,31H,14-17,19,21H2,1H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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