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Inhibitor Report for: Melatonin

Name Class
MelatoninTypeDerivative of Tryptamine
Indole
Not A/B H target
Natural
Other_Name (7)
Chemical_NomenclatureN-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
FormulaC13H16N2O2
CAS_number73-31-4
MW232.28
PaperZhao_2019_J.Pineal.Res__e12630
Structure6TR5
CommentMelatonin is a hormone produced by the pineal gland that has multiple effects including somnolence. The secretion of melatonin increases in darkness and decreases during exposure to light and is believed to play a role in regulation of the sleep-wake cycle. Melatonin is also implicated in the regulation of mood, learning and memory, immune activity, dreaming, fertility and reproduction. Melatonin is also an effective antioxidant. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors.
Gene_locushuman-NOTUM
CID896
FamilyPectinacetylesterase-Notum
InChIKeyDRLFMBDRBRZALE-UHFFFAOYSA-N
CanonicalSMILESCC(=O)NCCC1=CNC2=C1C=C(C=C2)OC
InChIInChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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