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Inhibitor Report for: MmPPOX

Name Class
MmPPOXTypeOxadiazolone
Oxadiazol
Lipase inhibitor
Phenoxyphenyl
Other_Name (8)
Chemical_Nomenclature5-methoxy-3-(3-phenoxyphenyl)-1,3,4-oxadiazol-2-one
FormulaC15H12N2O4
MW284.27
Kinetic_parameter (6)
Paper (7)
CommentIC50 around 250 nM. for LIPE but not very specific FAAH (IC50 6 nM) and MAGL (IC50 0.4 microM); hBAT5 (human-ABHD16A) 1-LG hydrolysis (IC50 8.3 nM
Gene_locushuman-LIPE
human-ABHD16A
CID18184779
FamilyAcidic_Lipase
Hormone-sensitive_lipase_like
ABHD16
InChIKeyMAWQNKAJQQKDTD-UHFFFAOYSA-N
CanonicalSMILESCOC1=NN(C(=O)O1)C2=CC(=CC=C2)OC3=CC=CC=C3
InChIInChI=1S/C15H12N2O4/c1-19-14-16-17(15(18)21-14)11-6-5-9-13(10-11)20-12-7-3-2-4-8-12/h2-10H,1H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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