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Inhibitor Report for: MmPPOX
Name
Class
MmPPOX
Type
Oxadiazolone
Oxadiazol
Lipase inhibitor
Phenoxyphenyl
Other_Name (8)
Chemical_Nomenclature
5-methoxy-3-(3-phenoxyphenyl)-1,3,4-oxadiazol-2-one
Formula
C15H12N2O4
MW
284.27
Kinetic_parameter (6)
Paper (7)
Comment
IC50 around 250 nM. for LIPE but not very specific FAAH (IC50 6 nM) and MAGL (IC50 0.4 microM); hBAT5 (human-ABHD16A) 1-LG hydrolysis (IC50 8.3 nM
Gene_locus
human-LIPE
human-ABHD16A
CID
18184779
Family
Acidic_Lipase
Hormone-sensitive_lipase_like
ABHD16
InChIKey
MAWQNKAJQQKDTD-UHFFFAOYSA-N
CanonicalSMILES
COC1=NN(C(=O)O1)C2=CC(=CC=C2)OC3=CC=CC=C3
InChI
InChI=1S/C15H12N2O4/c1-19-14-16-17(15(18)21-14)11-6-5-9-13(10-11)20-12-7-3-2-4-8-12/h2-10H,1H3
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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