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Inhibitor Report for: Mycophenolic-acid

Name Class
Mycophenolic-acidTypeNatural
Benzofuran
Other_Namemycophenolic acid
Mycophenolate
Myfortic
Melbex
MPA
MOA
CHEMBL866
CHEBI:168396
SCHEMBL4549
CHEBI:92545
Chemical_Nomenclature(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
FormulaC17H20O6
CAS_number24280-93-1
MW320.3
PaperYou_2021_FEBS.J_288_5768
Bentley_2000_Chem.Rev_100_3801
Structure7DBL
CommentMycophenolic acid (MPA) is a fungal natural product. Mycophenolic Acid is an antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. In the compartmentalized biosynthesis of MPA, the acyl-coenzyme A (CoA) hydrolase MpaH' located in peroxisomes catalyzes the highly specific hydrolysis of MPA-CoA to produce the final product MPA
Gene_locuspenbr-mpaH
CID446541
FamilyMpaH
InChIKeyHPNSFSBZBAHARI-RUDMXATFSA-N
CanonicalSMILESCC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)O)O
InChIInChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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