Inhibitor Report for: Mycophenolic-acid
| Mycophenolic-acid | Type | Natural |
|---|
| | Benzofuran |
| Other_Name (10) |
| Chemical_Nomenclature | (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoic acid |
| Formula | C17H20O6 |
| CAS_number | 24280-93-1 |
| MW | 320.3 |
|  |
| Paper | You_2021_FEBS.J_288_5768 |
| | Bentley_2000_Chem.Rev_100_3801 |
| Structure | 7DBL |
| Comment | Mycophenolic acid (MPA) is a fungal natural product. Mycophenolic Acid is an antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. In the compartmentalized biosynthesis of MPA, the acyl-coenzyme A (CoA) hydrolase MpaH' located in peroxisomes catalyzes the highly specific hydrolysis of MPA-CoA to produce the final product MPA |
| Gene_locus | penbr-mpaH |
| CID | 446541 |
| Family | MpaH |
| InChIKey | HPNSFSBZBAHARI-RUDMXATFSA-N |
| CanonicalSMILES | CC1=C2COC(=O)C2=C(C(=C1OC)CC=C(C)CCC(=O)O)O |
| InChI | InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+ |
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