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Substrate Report for: N-alanyl-secovicenilactam-ethyl-ester

Name Class
N-alanyl-secovicenilactam-ethyl-esterTypeAntibiotic
Analogue of substrate
Other_NameN-alanyl secovicenilactam ethyl ester
Chemical_NomenclatureN-alanyl-secovicenilactam-ethyl-ester
FormulaC28H46N2O4
MW474.68
PaperShinohara_2014_FEBS.Lett_588_995
Shinohara_2011_J.Am.Chem.Soc_133_18134
CommentAla captured polyketide intermediate. Elimination of Alanine by VinJ deprotects the compound for action of TE and final cylclisation in the biosynthesis of macrolactam polyketide antibiotics. Analogue of substrate which was used to mimic the elongated polyketide substrate attached to ACP. The compound was docked in the structure 3WMR (Shinohara 2014)
Gene_locusstrha-q76ky6
FamilyProline_iminopeptidase

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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