Database has been updated based on Pfam 18.0 UniProt 5.0 (a composite of SWISSPROT release 47.0 and SP-TrEMBL release 30.0). New families were created according to the clan Alpha/Beta hydrolase of the Pfam database: Tannase, Neuroligin. New papers are investigating the relationship with some forms of autism with mutations in neuroligins: Yan_2005_Mol.Psychiatry_10_329, Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285. See also the site of Dr Steve Sommer www.cityofhope.org/cmdl