Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Omarigliptin

Name Class
OmarigliptinTypeSulfur Compound
Gliptin
Pyrazole
Other_NameMK-3102
MK3102
UNII-CVP59Q4JE1
CVP59Q4JE1
Chemical_Nomenclature(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
FormulaC17H20F2N4O3S
CAS_number1226781-44-7
MW398.42
PaperBiftu_2014_J.Med.Chem_57_3205
Zhang_2023_Sci.Rep_13_14339
Structure4PNZ
CommentOmarigliptin is an investigational long-acting inhibitor of dipeptidyl peptidase 4 (DPP4). The first DPP4 inhibitor to be clinically approved was sitagliptin. This has subsequently been joined by several more drugs such as vildagliptin, saxagliptin, linagliptin and alogliptin.
Gene_locushuman-DPP4
CID46209133
FamilyDPP4N_Peptidase_S9
InChIKeyMKMPWKUAHLTIBJ-ISTRZQFTSA-N
CanonicalSMILESCS(=O)(=O)N1C=C2CN(CC2=N1)C3CC(C(OC3)C4=C(C=CC(=C4)F)F)N
InChIInChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
IupharLig8402
WikipediaOmarigliptin

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer