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Substrate Report for: PAF

Name Class
PAFType (5)
Other_NamePlatelet activating factor
Platelet-activating factor
C16-PAF
1-O-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine
Hag-PC
APRL
(1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
Chemical_Nomenclature[(2R)-2-acetyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
FormulaC26H54NO7P
CAS_number74389-68-7
MW523.68
PaperAarsman_1991_Eur.J.Biochem_200_187
CommentExtracellular signaling lipid; ligand for G protein-coupled platelet activating factor (PAF) receptors. Induces inflammation by increasing vascular permeability; activates MAP kinase (MAPK) and MAP kinase kinase (MAPKK) in CHO cells. PAF is a substrate for lysophospholipase II and for PAF-Acetyl hydrolase
CID108156
FamilyPAF-Acetylhydrolase
LYsophospholipase_carboxylesterase
InChIKeyHVAUUPRFYPCOCA-AREMUKBSSA-N
CanonicalSMILESCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C
InChIInChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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