Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT), Lecithin-cholesterol acyltransferase, belong to this family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. LACT also known as phosphatidylcholine-sterol acyltransferase (EC), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases. This family correspond to group XV phospholipase A2. Phospholipid:diacylglycerol acyltransferase (PDAT)(2.3.1.158) is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. A group of bacterial enzymes was extracted in a new family : Bacterial_EstLip_FamXIV