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Family Report for: PC-sterol_acyltransferase

Name Class
PC-sterol_acyltransferaseRank1
Gene_locus (92)
Gene_locus_Frgt (28)
BlockL
PrositePS00120
PdocPDOC00110
Paper (8)
Structure (14)
EC_number2.3.1.43
InterproIPR003386 Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase LACT/PDAT_acylTrfase
CommentLysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT), Lecithin-cholesterol acyltransferase, belong to this family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport, respectively. Whereas LPLA2 is predicted to underlie the development of drug-induced phospholipidosis, somatic mutations in LCAT cause fish eye disease and familial LCAT deficiency. LACT also known as phosphatidylcholine-sterol acyltransferase (EC), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases. This family correspond to group XV phospholipase A2. Phospholipid:diacylglycerol acyltransferase (PDAT)(2.3.1.158) is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid. A group of bacterial enzymes was extracted in a new family : Bacterial_EstLip_FamXIV
PfamPF02450 LACT-Lecithin:cholesterol acyltransferase LCAT
PrintsPR00821
Inhibitor (5)
Substrate (5)
ChemicalSCHEMBL1719815
DS-8190a
H94

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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