Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: PE-PPE

Name Class
PE-PPERank1
Gene_locus (92)
Gene_locus_Frgtmycs2-a0r3c3
9caud-d4p7q2
BlockX
Paper (7)
InterproIPR013228 PE-PPE, C-terminal
IPR000084 PE-PGRS family, N-terminal
CommentThis domain is found C-terminal to the PE (IPR000084) and PPE (IPR000030) domains. The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands, and recently demonstrated to be alpha/beta hydrolase: see Sultana et al. This protein domain is close to cutinase. The membrane-associated acyltransferase Chp1 (myctu-Rv3822) accepts a synthetic diacyl sulfolipid and transfers an acyl group regioselectively from one donor substrate molecule to a second acceptor molecule in two successive reactions to yield a tetraacylated product.The rv1184c locus encodes Chp2, an acyltransferase in polyacyltrehalose lipid biosynthesis In fact this domain is found in many unrelated folds only a few are alpha/beta hydrolases (Sultana 2016)
PfamPF08237 PE-PPE
NewsMARCH-O2-2011
InhibitorPMSF
Orlistat
SubstrateParanitrophenyl-hexanoate

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer