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Inhibitor Report for: PF-06795071
Name
Class
PF-06795071
Type (5)
Other_Name (7)
Chemical_Nomenclature
(1,1,1-trifluoro-3-hydroxypropan-2-yl) 6-[1-(4-fluorophenyl)pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carboxylate
Formula
C18H17F4N3O3
MW
399.34
Paper
McAllister_2018_J.Med.Chem_61_3008
Chen_2019_J.Med.Chem_62_8866
Chen_2021_Acta.Pharm.Sin.B_11_1686
Structure
6BQ0
Comment
Irreversible MAGL inhibitor. The adduct on the active serine without the leaving group is E3A FNIBKVOGYHDUDM-UOIKSKOESA-N. It is the same adduct for PF-06795071 and for compound 10 used in cristallization. [18F]PF06795071 developped as a PET probe
Gene_locus
human-MGLL
CID
126506472
Family
Monoglyceridelipase_lysophospholip
InChIKey
MEDCQBUTCWNKGW-UHFFFAOYSA-N
CanonicalSMILES
C1C2C(C2C3=NN(C=C3)C4=CC=C(C=C4)F)CN1C(=O)OC(CO)C(F)(F)F
InChI
InChI=1S/C18H17F4N3O3/c19-10-1-3-11(4-2-10)25-6-5-14(23-25)16-12-7-24(8-13(12)16)17(27)28-15(9-26)18(20,21)22/h1-6,12-13,15-16,26H,7-9H2
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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