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Inhibitor Report for: Phenothiazine

Name Class
PhenothiazineType (5)
Chemical_NomenclaturePhenothiazine
FormulaC12H9NS
CAS_number92-84-2
MW199.3
PaperSingh_1998_Comp.Biochem.Physiol.C.Pharmacol.Toxicol.Endocrinol_119_97
CommentTricyclic amine-containing compound
Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI)
CID7108
FamilyACHE
InChIKeyWJFKNYWRSNBZNX-UHFFFAOYSA-N
CanonicalSMILESC1=CC=C2C(=C1)NC3=CC=CC=C3S2
InChIInChI=1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H
WikipediaPhenothiazine

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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