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Family Report for: Phospholipase

Name Class
PhospholipaseRank1
Gene_locus (277)
Gene_locus_Frgt (19)
BlockL
PrositePS00120
PdocPDOC00110
PaperAoki_2007_Biochimie_89_197
Shanbhag_2020_J.Membr.Biol_253_381
Nagai_1999_J.Biol.Chem_274_11053
EC_number3.1.1.32
InterproIPR000734 Lipase
IPR002334 Dol/Ves 1 allergen
IPR016272 Lipase, LIPH-type
IPR013818 Lipase
CommentPhospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids and is conserved in a wide range of organisms. Hypotrichosis, or woolly hair with or without hypotrichosis hypotrichosis (deficiency of hair growth), can be caused by homozygous or compound heterozygous mutation in the LIPH (human-LIPH) gene on chromosome 3q27 (not hepatic lipase: human-LIPC). Other mammalian enzymes that exhibit PLA(1) activity in vitro are hepatic lipase HL endothelial lipase EL and pancreatic lipase-related protein 2 PLRP2 and belong to alpha/beta hydrolase superfamily.
PfamPF00151 Lipase
PIRSFPIRSF000865 lipoprotein lipase, LIPH type
PrintsPR00821
PR00825
Substrate (5)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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