Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Physostigmine~Eserine

Name Class
Physostigmine~EserineType (5)
Other_Name (29)
Chemical_Nomenclature1'methylpyrrolidino (2':3':2:3) 1,3-dimethylindolin-%-yl N-methylcarbamate
FormulaC15H21N3O2
CAS_number57-47-6
MW275.34
Kinetic_parameterPhysostigmine~Eserine_WT_human-BCHE
Physostigmine~Eserine_D70G_human-BCHE
Paper (92)
CommentCarbamate alkaloid purified from the calabar bean: Physostigma venenosum. Physostigmine is a cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Kin_InhibitorPhysostigmine~Eserine
CID (6)
FamilyACHE
BCHE
Arylacetamide_deacetylase
InChIKey (5)
CanonicalSMILESCC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C
CC12CC[NH+](C1[NH+](C3=C2C=C(C=C3)OC(=O)NC)C)C.C1=CC=C(C(=C1)C(=O)[O-])[O-]
CC12CC[NH+](C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.CC12CC[NH+](C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.[O-]S(=O)(=O)[O-]
CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.Br
InChI (5)
IupharLig6598
WikipediaPhysostigmine

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer