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Family Report for: Plant_lipase_EDS1-like

Name Class
Plant_lipase_EDS1-likeRank1
Gene_locus (167)
Gene_locus_Frgt (15)
BlockL
PrositePS00120
PdocPDOC00110
Paper (13)
Structure (10)
InterproIPR000734 Lipase
IPR044214 EDS1-like
IPR041266 EDS1, EP domain EDS1_EP
CommentEnhanced Disease Susceptibility 1 (EDS1), an essential component of R gene-mediated disease resistance. The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4. EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). This family is extracted from the Lipase3 gene family. The C-terminal domain known as the EP domain and its interface consists of hydrophobic interactions, salt bridges, and an extensive hydrogen bonding network. Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4) mediate TNL receptor defence signalling. (In the seed alignment and the HMM alignement the EP domain (not alpha/beta hydrolase domain) is excluded)
PfamPF01764 Lipase_3
PF18117 EDS1_EP
PrintsPR00821
SubstratepRib-AMP
ADP-ribose
pRib-ADP

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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