Family Report for: Plant_lipase_EDS1-like
Plant_lipase_EDS1-like | Rank | 1 |
| Gene_locus (167) |
| Gene_locus_Frgt (15) |
| Block | L |
| Prosite | PS00120 |
| Pdoc | PDOC00110 |
| Paper (13) |
| Structure (10) |
| Interpro | IPR000734 Lipase |
| | IPR044214 EDS1-like |
| | IPR041266 EDS1, EP domain EDS1_EP |
| Comment | Enhanced Disease Susceptibility 1 (EDS1), an essential component of R gene-mediated disease resistance. The Arabidopsis EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4. EDS1 (arath-eds1) and PAD4 (arath-F22O6.190) genes encode lipase-like proteins that function in resistance (R) gene-mediated and basal plant disease resistance. EDS1 can dimerize and interact with PAD4 or with SAG101 (arath-At5g14930). This family is extracted from the Lipase3 gene family. The C-terminal domain known as the EP domain and its interface consists of hydrophobic interactions, salt bridges, and an extensive hydrogen bonding network. Plants utilise intracellular nucleotide-binding, leucine-rich repeat (NLR) immune receptors to detect pathogen effectors and activate local and systemic defence. NRG1 and ADR1 'helper' NLRs (RNLs) cooperate with enhanced disease susceptibility 1 (EDS1), senescence-associated gene 101 (SAG101) and phytoalexin-deficient 4 (PAD4) lipase-like proteins to mediate signalling from TIR domain NLR receptors (TNLs). Two distinct modules (NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4) mediate TNL receptor defence signalling. (In the seed alignment and the HMM alignement the EP domain (not alpha/beta hydrolase domain) is excluded) |
| Pfam | PF01764 Lipase_3 |
| | PF18117 EDS1_EP |
| Prints | PR00821 |
| Substrate | pRib-AMP |
| | ADP-ribose |
| | pRib-ADP |
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