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Family Report for: PolyAspartate-hydrolase

Name Class
PolyAspartate-hydrolaseRank2
FamilyAbhydrolase_5
Gene_locus (56)
BlockX
PaperHiraishi_2011_Appl.Microbiol.Biotechnol_91_895
Hiraishi_2003_Biomacromolecules_4_80
Hiraishi_2009_Macromol.Biosci_9_10
Structure8DNB
6VE6
3D0K
CommentPoly(aspartate) (PAA) is a bio-based, biocompatible, biodegradable alternative to polycarboxylate of poly(acrylate). Bacterial PAA-hydrolyzing enzyme can also perform synthesis of poly(alpha-ethyl beta-aspartate). This family is close to PHB depolymerase. The LpqC, poly(3-hydroxybutyrate) depolymerase from Bordetella parapertussis (CASP Target) (structure 3D0K) belongs to this family. Polyaspartic acid (PASA) is also a natural polymer as fragment of larger proteins with length up to 50 amino acids. Synthetic tPAA(thermally synthesized PAA) consists of beta-amide (70%) and alpha-amide,(30%) D- and L-aspartate units; the alpha- and beta-amide units are randomly distributed. PAA hydrolase-1 is an alpha beta hydrolase inhibited by PMSF and DFP. PAA hydrolase-2 is closer to metallo carboxypeptidase inhibited by DFP and PMSF
PfamPF12695 Abhydrolase_5
InhibitorDFP
PMSF
SubstratePolyaspartic-acid
PHB

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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