Inhibitor Report for: Propargyl-Tacrine-15
Propargyl-Tacrine-15 | Type | Multitarget |
| | Monoamine-oxidase-inhibitor |
| | Derivative of Tacrine |
| | Alkyne |
| Formula | C22H20N2O |
| MW | 328.41 |
| |
| Paper | Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| Comment | balanced pharmacological profile [IC(50) (hAChE) = 1.472+/-0.024 microM; IC(50) (hBChE) = 0.659+/-0.077 microM; IC(50) (hMAO-B) = 40.39+/-5.98nM] |
| Gene_locus | human-BCHE |
| | human-ACHE |
| Family | BCHE |
| | ACHE |
| InChIKey | IBMLQDVOCDHFMT-UHFFFAOYSA-N |
| CanonicalSMILES | [C]1=[C][C]=[C]C(=[C]1)OC2=[C][C]=C3C(=[C]2)C(=C4C(=N3)CCCC4)[N]CC#[C] |
| InChI | InChI=1S/C22H20N2O/c1-2-14-23-22-18-10-6-7-11-20(18)24-21-13-12-17(15-19(21)22)25-16-8-4-3-5-9-16/h1,3-5,8-9,12-13,15H,6-7,10-11,14H2,(H,23,24) |
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