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Inhibitor Report for: Pyrazolone-27

Name Class
Pyrazolone-27TypePyrazole
Chemical_Nomenclature1-cyclohexyl-4-(4-methylbenzyl)-3-p-tolyl-1H-pyrazol-5(4H)-one
FormulaC24H28N2O
MW360.49
PaperQian_2021_Bioorg.Med.Chem_40_116187
Commentnon-competitive inhibition. human-CES2 IC50 0.13 +/- 0.01 microM
Gene_locushuman-CES2
FamilyCarb_B_Chordata
InChIKeyWIXUXAFPTNJYDK-UHFFFAOYSA-N
CanonicalSMILESN1=C(C(C(N1C2CCCCC2)=O)CC3=CC=C(C=C3)C)C4=CC=C(C=C4)C
InChIInChI=1S/C24H28N2O/c1-17-8-12-19(13-9-17)16-22-23(20-14-10-18(2)11-15-20)25-26(24(22)27)21-6-4-3-5-7-21/h8-15,21-22H,3-7,16H2,1-2H3

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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