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Inhibitor Report for: Pyrrole-26-6YSK
Name
Class
Pyrrole-26-6YSK
Type
Pyrrole_Pyrrolidine-derivative
Trifluoro
Other_Name
PJK
(3~{S})-1-[4-chloranyl-3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid
Chemical_Nomenclature
(3S)-1-[4-chloro-3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid
Formula
C12H11ClF3NO2
MW
293.67
Paper
Mahy_2020_J.Med.Chem_63_9464
Structure
6YSK
Comment
IC50 0.11 +/- 0.01 microM Notum with OPTS substrate
Gene_locus
human-NOTUM
CID
154585553
Family
Pectinacetylesterase-Notum
InChIKey
XTYYFZCQCKEYKG-ZETCQYMHSA-N
CanonicalSMILES
C1CN(CC1C(=O)O)C2=CC(=C(C=C2)Cl)C(F)(F)F
InChI
InChI=1S/C12H11ClF3NO2/c13-10-2-1-8(5-9(10)12(14,15)16)17-4-3-7(6-17)11(18)19/h1-2,5,7H,3-4,6H2,(H,18,19)/t7-/m0/s1
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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