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Substrate Report for: S-Formylglutathione

Name Class
S-FormylglutathioneTypePeptide
Other_NameL-gamma-glutamyl-S-formyl-L-cysteinylglycine
AC1L4O3B
SCHEMBL380154
CHEBI:16225
Chemical_Nomenclature(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-formylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
FormulaC11H17N3O7S
CAS_number50409-81-9
MW335.33
PaperGonzalez_2006_J.Biol.Chem_281_14514
Commentdetoxification of Formaldehyde: S-Hydroxymethylglutathione is spontaneously formed from the reaction of formaldehyde and glutathione. S-Formylglutathione is the product of formaldehyde dehydrogenase, an enzyme which catalyzes the oxidation of S-hydroxymethylglutathione. SFGH catalyzes the hydrolysis of S-formylglutathione to produce formate and glutathione. Formate is then oxidized to carbon dioxide by formate dehydrogenase, and glutathione is recycled in subsequent detoxification reactions.
Gene_locushuman-ESD
CID189122
FamilyA85-EsteraseD-FGH
Antigen85c
InChIKeyFHXAGOICBFGEBF-BQBZGAKWSA-N
CanonicalSMILESC(CC(=O)NC(CSC=O)C(=O)NCC(=O)O)C(C(=O)O)N
InChIInChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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