A special issue on alpha/beta hydrolases is being published in Protein Peptide Letters. It includes the following papers: list of papers. We took the opportunity of the publication by Bahl and Madden on Pseudomonas Cif and structure of a H177Y mutant (3PI6) to isolate a new family CFTR-inhibitory-factor_Cif among epoxide hydrolase-like family. An important paper by Long et al. on ABHD3 function is published