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Inhibitor Report for: Sarin

Name Class
SarinTypeChemical Warfare Agent
Organophosphate
Nerve Agent G-series
Derivative of Sarin
Other_Name (11)
Chemical_Nomenclature2-[fluoro(methyl)phosphoryl]oxypropane
FormulaC4H10FO2P
CAS_number107-44-8
MW140.09
Paper (48)
Structure (12)
CommentThe organophosphate nerve agents tabun (GA), sarin (GB), soman (GD), and cyclosarin (GF) are among the most toxic chemical warfare agents known. The G-series nerve agents are named because German scientists led by Dr Gerhard Schraderfirst synthesized them during World War II, beginning with GA in 1936. GB was discovered next in 1938, followed by GD in 1944 and finally GF in 1949. The only other known nerve agent, O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX), V-series - VE, VG, VM, Russian VX). G-series nerve agents share a number of common physical and chemical properties. At room temperature, the G-series nerve agents are volatile liquids, making them a serious risk for 2 types of exposure: dermal contact with liquid nerve agent or inhalation of nerve agent vapor.Sarin is an acronym for the names of the members of the development team: Schrader. Ambrose. Rudriger. and van der Linde. The Germans deignated it T-I44 or Trilon-46. The United Slates eventually designated it GB
Gene_locushuman-ACHE
human-BCHE
human-CTSA
CID7871
FamilyACHE
BCHE
PAF-Acetylhydrolase
Carboxypeptidase_S10
InChIKeyDYAHQFWOVKZOOW-UHFFFAOYSA-N
CanonicalSMILESCC(C)OP(=O)(C)F
InChIInChI=1S/C4H10FO2P/c1-4(2)7-8(3,5)6/h4H,1-3H3
WikipediaSarin

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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