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Inhibitor Report for: Tamoxifen

Tamoxifen	Type	Drug
		Not A/B H target
	Other_Name (9)
	Chemical_Nomenclature	2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine
	Formula	C26H29NO
	MW	371.51
	Paper	Redinbo_2005_Drug.Discov.Today_10_313
		Mesange_2002_Bioconjug.Chem_13_766
		de Medina_2010_Proc.Natl.Acad.Sci.U.S.A_107_13520
		Fleming_2005_J.Mol.Biol_352_165
	Structure	1YA4
	Comment	Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue (a non-steroidal estrogen receptor antagonist used to treat breast cancer), but as an estrogen (stimulating agent) in cholesterol metabolism, bone density. It is hydrolyzed by carboxylesterase
	Gene_locus	human-CES1
	CID	2733526
	Family	Carboxylesterase
		Carb_B_Chordata
	InChIKey	NKANXQFJJICGDU-QPLCGJKRSA-N
	CanonicalSMILES	CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
	InChI	InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
	Wikipedia	Tamoxifen