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Reactivator Report for: Tryptoline-hydroxy-pyridinaldoxime-4

Name Class
Tryptoline-hydroxy-pyridinaldoxime-4TypeOxime
Pyridine-aldoxime
Chemical_Nomenclature2-[(E)-hydroxyiminomethyl]-6-[5-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)pentyl]pyridin-3-ol
FormulaC22H26N4O2
MW378.5
PaperRenou_2014_Chem.Commun.(Camb)_50_3947
CommentCompound 4 is as efficient as HI-6 for VX-hAChE, while3 equals trimedoxime for tabun-hAChE.In comparison with pralidoxime,3 and 4 are up to 30-fold more efficient for VX-AChE, up to 60-fold more efficient for tabun-AChE and up to 10-fold more efficient for paraoxon-AChE
CID136268844
InChIKeyQHSDCXRFORBVFT-OEAKJJBVSA-N
CanonicalSMILESC1CN(CC2=C1C3=CC=CC=C3N2)CCCCCC4=NC(=C(C=C4)O)C=NO
InChIInChI=1S/C22H26N4O2/c27-22-10-9-16(24-20(22)14-23-28)6-2-1-5-12-26-13-11-18-17-7-3-4-8-19(17)25-21(18)15-26/h3-4,7-10,14,25,27-28H,1-2,5-6,11-13,15H2/b23-14+

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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