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Inhibitor Report for: UW-MD-71
Name
Class
UW-MD-71
Type
Quinazoline
Multitarget
Histamine-Receptor3-H3-Antagonist
Other_Name
CHEMBL3323035
BDBM50053435
Chemical_Nomenclature
(7-(3-(piperidin-1-yl)propoxy)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
Formula
C19H27N3O
MW
313.44
Paper
Khan_2015_Behav.Brain.Res_297_155
Sadek_2016_Physiol.Behav_165_383
Darras_2014_ACS.Chem.Neurosci_5_225
Comment
excellent selectivity profiles over both the three other HRs as well as butyrylcholinesterase (BChE) shows high and balanced in vitro affinities at both H3R and AChE with IC50 of 33.9nM and hH3R antagonism with Ki of 76.2nM, respectively
CID
118710487
Family
ACHE
BCHE
Cholinesterase
InChIKey
UVYNECUSQBZMSD-UHFFFAOYSA-N
CanonicalSMILES
C1CCN(CC1)CCCOC2=CC3=C(C=C2)N=C4CCCN4C3
InChI
InChI=1S/C19H27N3O/c1-2-9-21(10-3-1)11-5-13-23-17-7-8-18-16(14-17)15-22-12-4-6-19(22)20-18/h7-8,14H,1-6,9-13,15H2
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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