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Inhibitor Report for: UW-MD-71

Name Class
UW-MD-71TypeQuinazoline
Multitarget
Histamine-Receptor3-H3-Antagonist
Other_NameCHEMBL3323035
BDBM50053435
Chemical_Nomenclature(7-(3-(piperidin-1-yl)propoxy)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline
FormulaC19H27N3O
MW313.44
PaperKhan_2015_Behav.Brain.Res_297_155
Sadek_2016_Physiol.Behav_165_383
Darras_2014_ACS.Chem.Neurosci_5_225
Commentexcellent selectivity profiles over both the three other HRs as well as butyrylcholinesterase (BChE) shows high and balanced in vitro affinities at both H3R and AChE with IC50 of 33.9nM and hH3R antagonism with Ki of 76.2nM, respectively
CID118710487
FamilyACHE
BCHE
Cholinesterase
InChIKeyUVYNECUSQBZMSD-UHFFFAOYSA-N
CanonicalSMILESC1CCN(CC1)CCCOC2=CC3=C(C=C2)N=C4CCCN4C3
InChIInChI=1S/C19H27N3O/c1-2-9-21(10-3-1)11-5-13-23-17-7-8-18-16(14-17)15-22-12-4-6-19(22)20-18/h7-8,14H,1-6,9-13,15H2

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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