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Inhibitor Report for: WWL113

Name Class
WWL113TypeCarbamate
Benzoate
Other_Name (5)
Chemical_Nomenclatureethyl 4-[4-[methyl-[(3-pyridin-4-ylphenyl)methyl]carbamoyl]oxyphenyl]benzoate
FormulaC29H26N2O4
CAS_number947669-86-5
MW466.52
PaperTurcotte_2019_J.Leukoc.Biol_106_1337
Dominguez_2014_Nat.Chem.Biol_10_113
Galmozzi_2014_Cell.Rep_9_1584
Yang_2019_Diabetes_68_1178
CommentCarboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active. The ability of WWL113 to induce UCP1 expression in brown adipocytes does not appear to be mediated by Ces3/1f inhibition, for a structurally distinct Ces3 inhibitor (WWL229) failed to have the same effect on UCP1 expression, whereas the urea version of WWL113 (WWL113U), which does not inhibit Ces3, retained the ability to induce UCP1
Gene_locushuman-ABHD6
human-CES3
mouse-Ces1d
CID17759482
Family (2)
InChIKeyAKIIPHDGVCFVCC-UHFFFAOYSA-N
CanonicalSMILESCCOC(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)OC(=O)N(C)CC3=CC=CC(=C3)C4=CC=NC=C4
InChIInChI=1S/C29H26N2O4/c1-3-34-28(32)25-9-7-22(8-10-25)23-11-13-27(14-12-23)35-29(33)31(2)20-21-5-4-6-26(19-21)24-15-17-30-18-16-24/h4-19H,3,20H2,1-2H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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