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Inhibitor Report for: WWL153

Name Class
WWL153TypePiperazine
Quinoline
pNP
Other_Name (5)
Chemical_Nomenclature(4-nitrophenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate
FormulaC21H20N4O4
MW392.4
PaperNagano_2013_Bioorg.Med.Chem.Lett_23_839
Bachovchin_2010_Proc.Natl.Acad.Sci.U.S.A_107_20941
CommentJMN4 exhibited superior potency for inhibiting recombinant mouse (IC50 = 90 nM) and human (IC50 = 5.9 nM) Lp-PLA2 compared to either WWL153 (IC50 = 290 nM for mouse Lp-PLA2; IC50 = 250 nM for human Lp-PLA2) or P9 (IC50 = 470 nM for mouse Lp-PLA2; IC50 = 100 nM for human Lp-PLA2)
Gene_locushuman-PLA2G7
CID46829224
FamilyPAF-Acetylhydrolase
InChIKeyMJCKCSRESUVXIX-UHFFFAOYSA-N
CanonicalSMILESCC1=NC2=CC=CC=C2C(=C1)N3CCN(CC3)C(=O)OC4=CC=C(C=C4)[N+](=O)[O-]
InChIInChI=1S/C21H20N4O4/c1-15-14-20(18-4-2-3-5-19(18)22-15)23-10-12-24(13-11-23)21(26)29-17-8-6-16(7-9-17)25(27)28/h2-9,14H,10-13H2,1H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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