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Mutation Report for: Y72A/W286A_human-ACHE

Name Class
Y72A/W286A_human-ACHEGene_locushuman-ACHE
Torpedo_number70,279
70
279
AA_ChangeY72A/W286A
Mode_of_mutationSite directed mutagenesis
ModificationPeripheral Anionic Site
SummaryPeripheral Anionic Site;Ki of PAS ligand increased >10X;Barak_1994_J.Biol.Chem_269_6296;Shafferman_1995_5th.ChE.Meeting.Madras__189
PaperBarak_1994_J.Biol.Chem_269_6296
Shafferman_1995_5th.ChE.Meeting.Madras__189
Kinetic_parameter (6)
Commentp.Y72A/W286A Tyr72Ala/Trp286Ala (p.Y103A/W317A Tyr103Ala/Trp317Ala in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site;Ki of PAS ligand increased >10X

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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