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Mutation Report for: Y72N/Y124Q/W286A/F295L/F297V/Y337A/V407F_human-ACHE

Name Class
Y72N/Y124Q/W286A/F295L/F297V/Y337A/V407F_human-ACHEGene_locushuman-ACHE
Torpedo_number70
121
279
288
290
330
400
70,121,279,288,290,330,400
AA_ChangeY72N/Y124Q/W286A/F295L/F297V/Y337A/V407F
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
SummaryAcyl specificity; Acyl pocket V407F does not increase kcat of the hexamutant;Barak_2002_Biochemistry_41_8245
PaperBarak_2002_Biochemistry_41_8245
Commentp.Tyr72Asn/Tyr124Gln/Trp286Ala/Phe295Leu/Phe297Val/Tyr337Ala/Val407Phe
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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