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Substrate Report for: Z-KR-pNA

Name Class
Z-KR-pNATypeBenzyloxycarbonyl
Peptide
p-nitroaniline
Other_NameZINC71788455
Cbz-DL-Lys-DL-Arg-pNA
Cbz-Lys-Arg-pNA
Z-Lys-Arg-pNA
Z-Lys-Arg-pNA inverted exclamation mark currency 2 HCl
Chemical_Nomenclaturebenzyl N-[(2S)-6-amino-1-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]carbamate
FormulaC26H36N8O6
MW556.6
PaperPetrenko_2021_Biology.(Basel)_10_1021
CommentA chromogenic substrate that permits direct measurement of peptide hydrolase activity, e.g., Cathepsin B, papain, trypsin, pOP, BACE (not specific), by colorimetry. The substrate liberates p-nitroaniline as a chromogenic product CID 44134613 is the hydrochloride form Cbz-DL-Arg-DL-Arg-pNA.2HCl
Gene_locus9gamm-b3vi58
CID95566027
FamilyS9N_PREPL_Peptidase_S9
InChIKeyGSXIDHCDZTUNBT-VXKWHMMOSA-N
CanonicalSMILESC1=CC=C(C=C1)COC(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-]
InChIInChI=1S/C26H36N8O6/c27-15-5-4-9-22(33-26(37)40-17-18-7-2-1-3-8-18)24(36)32-21(10-6-16-30-25(28)29)23(35)31-19-11-13-20(14-12-19)34(38)39/h1-3,7-8,11-14,21-22H,4-6,9-10,15-17,27H2,(H,31,35)(H,32,36)(H,33,37)(H4,28,29,30)/t21-,22-/m0/s1

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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