Gene_Locus Report

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Gene_locus Report for: human-ABHD6

Name Class
human-ABHD6Name Homo sapiens (Human) ABHD6 Monoacylglycerol lipase EC: 3.1.1.23
SpeciesHomo sapiens
Organismman
Gene_nameABHD6
BlockX
FamilyABHD6-Lip
Database (11)
Paper (53)
CommentMonoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzympe hydrolyzing 26AG.(belong to Monoglyceridelipase_lysophospholip family) ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999. Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al. A study by Wei et al. shows that ABHD6 negatively regulates the surface delivery and synaptic function of AMPA receptors independantly of hydrolase activity
Q9BV23 and Q9HBL9 differ only at cterminus (alternative splicing?)Q6ZMF7 hypothetical protein flj23958
Proteinhuman-ABHD6
Peptidehuman-ABHD6
Structure7OTS
Inhibitor (20)
Substrate (5)
Tree_nodeABHD6-Lip22518
Epoxide-hydrolase_like189099
Structure299190
OldTremblB2R7Y9

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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