The gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain contains the EH catalytic activity. The N-terminal domain, has high homology to the haloacid dehalogenase family of phosphatases (not alpha/beta hydrolase and not included in ESTHER 5MWA is a structure of this part of the protein). Only c-term PfamA Abhydrolase_1 286 540 N-term is HAD haloacid dehalogenase