Gene_Locus Report

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Gene_locus Report for: human-EPHX2

Name Class
human-EPHX2Name Homo sapiens (Human) epoxide hydrolase 2, Bifunctional epoxide hydrolase 2 cytosolic (EPHX2) (EC 3.3.2.3) Lipid-phosphate phosphatase (EC 3.1.3.76) Soluble epoxide hydrolase
EC_number3.3.2.3
3.1.3.76
SpeciesHomo sapiens
Organismman
Gene_nameEPHX2
sEH
BlockX
FamilyEpoxide_hydrolase
Risk_factorHypercholesterolemia, familial due to LDLR defect, modifier of
Database (14)
Paper (63)
CommentThe gene EPXH2 encodes for the soluble epoxide hydrolase (sEH), an enzyme involved in the regulation of cardiovascular and renal physiology containing two distinct domains connected via a proline-rich linker. The C-terminal domain contains the EH catalytic activity. The N-terminal domain, has high homology to the haloacid dehalogenase family of phosphatases (not alpha/beta hydrolase and not included in ESTHER 5MWA is a structure of this part of the protein). Only c-term PfamA Abhydrolase_1 286 540 N-term is HAD haloacid dehalogenase
Sequencehuman-EPHX2
Proteinhuman-EPHX2
Peptidehuman-EPHX2
MutationR287Q_human-EPHX2
Structure (119)
Inhibitor (107)
Substrate (8)
Fastaseqhuman-EPHX2
Tree_nodeEpoxide-hydrolase_like187172
Epoxide_hydrolase191369
Structure298751
OldTremblQ16764
B3KTU8
B3KUA0

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
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