Gene_locus Report for: human-ESD
human-ESD | Name | Homo sapiens (Human) esterase D (EC 3.1.1.1) formylglutathione hydrolase |
| Species | Homo sapiens |
| Organism | man |
| Gene_name | esd |
| Block | X |
| Family | A85-EsteraseD-FGH |
| Database (12) |
| Paper (9) |
| Comment | Q9BVJ2 (Homo sapiens (Human) similar to esterase 10) one aa different from P10768 |
| | Human esterase D (hEstD),1 also called S-formylglutathione hydrolase (SFGH, EC 3.1.2.12), is a ubiquitous intracellular carboxylesterase (CE). hEstD can be found in blood cells and most human tissues and is one of the major CE activities detectable in cytosolic fractions of human liver. SFGH hydrolyzes a range of uncharged ester substrates in vitro, including p-nitrophenyl acetate (pNPA) and 4-methylumbelliferyl acetate. EstD is a thioesterase involved in the removal of genotoxic formaldehyde via a glutathione-dependent reaction. The enzyme may also play a role in xenobiotic metabolism. EstD can be induced in human cells by exposure to methylmethane sulfonate or phenobarbital |
| Protein | human-ESD |
| Peptide | human-ESD |
| Structure | 3FCX |
| Substrate | S-Formylglutathione |
| | 4-methylumbelliferyl-acetate |
| Tree_node | A85-EsteraseD-FGH13161 |
| | Antigen85c73089 |
| | Structure299616 |
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