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Gene_locus Report for: human-ESD

Name Class
human-ESDName Homo sapiens (Human) esterase D (EC 3.1.1.1) formylglutathione hydrolase
SpeciesHomo sapiens
Organismman
Gene_nameesd
BlockX
FamilyA85-EsteraseD-FGH
Database (12)
Paper (9)
CommentQ9BVJ2 (Homo sapiens (Human) similar to esterase 10) one aa different from P10768
Human esterase D (hEstD),1 also called S-formylglutathione hydrolase (SFGH, EC 3.1.2.12), is a ubiquitous intracellular carboxylesterase (CE). hEstD can be found in blood cells and most human tissues and is one of the major CE activities detectable in cytosolic fractions of human liver. SFGH hydrolyzes a range of uncharged ester substrates in vitro, including p-nitrophenyl acetate (pNPA) and 4-methylumbelliferyl acetate. EstD is a thioesterase involved in the removal of genotoxic formaldehyde via a glutathione-dependent reaction. The enzyme may also play a role in xenobiotic metabolism. EstD can be induced in human cells by exposure to methylmethane sulfonate or phenobarbital
Proteinhuman-ESD
Peptidehuman-ESD
Structure3FCX
SubstrateS-Formylglutathione
4-methylumbelliferyl-acetate
Tree_nodeA85-EsteraseD-FGH13161
Antigen85c73089
Structure299616

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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