Gene_Locus Report

Biblio print

Add to basket

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Gene_locus Report for: human-KANSL3

Name Class
human-KANSL3NameHomo sapiens (Human) KAT8 regulatory NSL complex subunit 3, Testis development protein PRTD, KIAA1310, PRTD, SI1, FLJ10081, NSL3, Rcd1
SpeciesHomo sapiens
Organismhuman
Gene_name (6)
BlockX
FamilyNLS3-Tex30
Database (11)
Paper (12)
CommentOld K1310_HUMAN human-Q86T19.
only central part Pfam A Abhydrolase_5 289 436. KANSL3 is a subunit of a nonspecific lethal (NSL) histone acetyltransferase (HAT) complex that acetylates core histone H4. NSL3 and the O-linked N-acetylglucosamine (O-GlcNAc) transferase OGT1 are subunits of an NSL HAT complex that acetylates histone H4 residues lys5 (K5), K8, and K16. Knockdown of OGT1 or NSL3 reduced global H4K16 acetylation in a dose-dependent manner. Immunoprecipitation analysis in HEK293 and HeLa cells revealed that endogenous OGT1 and NSL3 interacted, and mutation analysis revealed that the N-terminal TPR repeat domain of OGT1 interacted with the abhydrolase domain of NSL3. In vitro, OGT1 catalyzed O-GlcNAc modification of NSL3 in the presence of donor UDP-GlcNAc. The O-GlcNAc modification stabilized NSL3, and stabilized NSL3 was required for H4K16 acetylation by the HAT NSL complex
Proteinhuman-KANSL3
Peptidehuman-KANSL3
Tree_nodeNLS3-Tex30259470
OldTremblQ86T19
Q96L64

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer