Gene_locus Report for: human-KANSL3
human-KANSL3 | Name | Homo sapiens (Human) KAT8 regulatory NSL complex subunit 3, Testis development protein PRTD, KIAA1310, PRTD, SI1, FLJ10081, NSL3, Rcd1 |
| Species | Homo sapiens |
| Organism | human |
| Gene_name (6) |
| Block | X |
| Family | NLS3-Tex30 |
| Database (11) |
| Paper (12) |
| Comment | Old K1310_HUMAN human-Q86T19. |
| | only central part Pfam A Abhydrolase_5 289 436. KANSL3 is a subunit of a nonspecific lethal (NSL) histone acetyltransferase (HAT) complex that acetylates core histone H4. NSL3 and the O-linked N-acetylglucosamine (O-GlcNAc) transferase OGT1 are subunits of an NSL HAT complex that acetylates histone H4 residues lys5 (K5), K8, and K16. Knockdown of OGT1 or NSL3 reduced global H4K16 acetylation in a dose-dependent manner. Immunoprecipitation analysis in HEK293 and HeLa cells revealed that endogenous OGT1 and NSL3 interacted, and mutation analysis revealed that the N-terminal TPR repeat domain of OGT1 interacted with the abhydrolase domain of NSL3. In vitro, OGT1 catalyzed O-GlcNAc modification of NSL3 in the presence of donor UDP-GlcNAc. The O-GlcNAc modification stabilized NSL3, and stabilized NSL3 was required for H4K16 acetylation by the HAT NSL complex |
| Protein | human-KANSL3 |
| Peptide | human-KANSL3 |
| Tree_node | NLS3-Tex30259470 |
| OldTrembl | Q86T19 |
| | Q96L64 |
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