only n-term Pfam A PGAP1 82 302 is the alpha/beta hydrolase domain. PGAP1Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.Mutations in PGAP1 result in the disease: Mental retardation, autosomal recessive 42 (MRT42). A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Hereditary spastic paraplegias (HSPs) SPG67