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Gene_locus Report for: myctu-Rv3097c

Name Class
myctu-Rv3097cNameMycobacterium tuberculosis, Mycobacterium bovis, Rv3097c lipY PE-PGRS family protein triglycerol acyl hydrolase esterase/lipase
SpeciesMycobacterium tuberculosis
Organismbacteria
Gene_name (19)
BlockH
FamilyHormone-sensitive_lipase_like
Database (8)
Paper (19)
Comment(from Uniprot) Catalyzes the hydrolysis of both intracellular and extracellular triacylglycerol (TAG). In vitro, can also hydrolyze p-nitrophenyl (pNP) esters with various chain lengths, including pNP-acetate (C2), pNP-butyrate (C4), pNP-caproate (C6), pNP-caprylate (C8), pNP-laurate (C12), pNP-myristate (C14), pNP-palmitate (C16) and pNP-stearate (C18). Also hydrolyzes monobutyrin, tributyrin and trioctanoin. Overexpression results in increase of virulence characterized by reduced survival of infected mouse and increased burden of bacilli in the lungs. Hydrolyzes internal or host-derived TAG depending on its localization. Hydrolyzes TAG that accumulates within mycobacterial intracytosolic lipid inclusions (ILI). Probably responsible for the utilization of stored long-chain TAG during the dormancy and reactivation stages of the pathogen. N-terminal also homologous to PE subfamily of glycine-rich proteins. PE proteins cross the unique cell wall that protects the pathogen from eradication by the immune system through the type VII secretion or ESX systems. PE_PGRS domain is processed by PecA an aspartic protease. There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains.
Sequencemyctu-Rv3097c
Proteinmyctu-Rv3097c
Peptidemyctu-Rv3097c
InhibitorCpd8f-quinoline-carboxamide
Cyclipostin-P
CommentOtherStrainsmyctu-Rv3097c
Tree_nodeHormone-sensitive_lipase_like226710

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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